منابع مشابه
Metabolic fate and pharmacokinetics of the acyclovir prodrug valaciclovir in cynomolgus monkeys.
Valaciclovir, the L-valyl ester of acyclovir (ZOVIRAX), demonstrated good oral absorption and nearly complete conversion to acyclovir in cynomolgus monkeys, indicating its suitability as an orally administered prodrug. The major urinary metabolites of [8-14C]valaciclovir, administered orally (10 and 25 mg/kg) or intravenously (10 mg/kg) to male monkeys, were acyclovir (46%-59% of urinary radioa...
متن کاملInfluence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients.
This study was performed to investigate the pharmacokinetics of valaciclovir (VACV), aciclovir (ACV) and 9-(carboxymethoxy)methylguanine (CMMG) in Japanese chronic hemodialysis patients following a single oral administration of 1000 mg VACV and the influence of genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) on their pharmacokinetics. A total of eighteen individuals genotyped as ALDH2...
متن کاملEffect of oral valaciclovir on herpetic keratitis.
PURPOSE To examine the efficacy of valaciclovir (VACV) oral formulation as an alternative to topical treatments in a case of herpetic keratitis. METHODS The patient was a 61-year-old man who presented with dendritic keratitis in his left eye. After recognizing his difficulty in using eye ointment, we prescribed oral VACV 500 mg tablets twice daily for 7 days. We also describe our experiments ...
متن کاملAciclovir and valaciclovir neurotoxicity in patients with renal failure.
Nefrologia 2012;32(1):114-32 Furthermore, Mastorakos et al. reported that plasma antidiuretic hormone levels were elevated after IL-6 injection in cancer patients, suggesting that IL-6 activated the magnocellular ADHsecreting neurons and that it might be involved in SIADH. Activation of the subfornical organ and the organum vasculosum of the lamina terminalis by IL-6 could eventually lead to th...
متن کاملZona ophtalmique à localisation palpébrale: bonne évolution sous valaciclovir
Je traite dans cette image le cas d'une patiente suivie dans notre formation, âgée de 55 ans sans antécédents pathologiques notables qui consulte aux urgences pour douleur, éruption cutanée au niveau de l'hémifront droit et la paupière supérieure non prurigineuse avec larmoiement et photophobie depuis une semaine. L'examen clinique trouve un œdème palpébral important unilatéral droit avec des l...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2004
ISSN: 1460-2091
DOI: 10.1093/jac/dkh244